Personalized,
bio-engineered, dermo-epidermal skin grafts

After more than 20 years of research and development, our lead product denovoSkin™ promises to take skin surgery to the next level and revolutionize current treatments.

denovoSkin™ is an advanced therapy medicinal product (biologic). It is a personalized human skin graft that can be bio-engineered in large  quantities, starting from a small, post stamp-sized piece of healthy skin. It promises to grow with the patient, limit scarring, and drastically reduce the number of follow up corrective surgeries required, particularly in children. The outcome is potentially life-saving and life-changing. 

denovoSkin™ is in late-stage clinical trials in Switzerland and the European Union and also accessible for compassionate use. denovoSkin™ has been granted Orphan Drug Designation for the treatment of burns from Swissmedic, EMA, and FDA.

Personalized,
bio-engineered, dermo-epidermal skin grafts

After more than 20 years of research and development, our lead product denovoSkin™ promises to take skin surgery to the next level and revolutionize current treatments.

denovoSkin™ is an advanced therapy medicinal product (biologic). It is a personalized human skin graft that can be bio-engineered in large  quantities, starting from a small, post stamp-sized piece of healthy skin. It promises to grow with the patient, limit scarring, and drastically reduce the number of follow up corrective surgeries required, particularly in children. The outcome is potentially life-saving and life-changing. 

denovoSkin™ is in late-stage clinical trials in Switzerland and the European Union and also accessible for compassionate use. denovoSkin™ has been granted Orphan Drug Designation for the treatment of burns from Swissmedic, EMA, and FDA.

Proprietary manufacturing process

To bio-engineer denovoSkin™, a small biopsy of healthy skin is harvested from the patient. The biopsy is processed to isolate epidermal and dermal cells. The cells are expanded in vitro (can be bio-banked for further use) and thereafter used in combination with a hydrogel for tissue formation.

denovoSkin™, a dermo-epidermal personalizes skin graft, is now ready for grafting. Its mode of action is permanent take.

©Susanne Staubli University Children's Hospital Zurich
@Susanne Staubli University Children's Hospital Zurich

Potential

denovoSkin™ has a large potential. It could be of great benefit to patients with burns, skin traumas, those that undergo reconstructive or plastic procedures, as well as for patients with skin cancer or cutaneous congenital malformations.

denovoSkin™ is a patented, personalized, autologous bio-engineered human skin graft classified as Advanced Therapy Medicinal Product (ATMP) in the EU. It is engineered in large quantities starting from a stamp-sized skin biopsy of the patient, thereby addressing the issue of donor site shortages. 

Moreover, because of its dermo-epidermal structure, denovoSkin™ promises to lead to minimal scarring after transplantation. This considerably reduces further corrective interventions and post-surgery home care, allowing also for considerable healthcare cost savings.

©Wyss Zurich
©WyssZurich

Automated manufacturing for
scale up

Skin is our largest organ – adults carry around 3.6 kilograms and 2 square meters of it. The bio-engineering of personalized skin tissue therapy faces scale up challenges.

At CUTISS we are working on the translation of the current manual manufacturing process into an automated, fully closed one. 

Automation is expected to decrease production costs and time, ensure robustness of the process, and allow for the de-centralization of manufacturing.

We have developed our own unique approach to bioengineering human skin tissue composed of three modules: cell isolation (Semotiss™, CUTISS proprietary technology), cell expansion (Quantum®, TERUMO), and skin tissue formation (denovoCast™, CUTISS proprietary technology).

Automated manufacturing for
scale up

Skin is our largest organ – adults carry around 3.6 kilograms and 2 square meters of it. The bio-engineering of personalized skin tissue therapy faces scale up challenges.

At CUTISS we are working on the translation of the current manual manufacturing process into an automated, fully closed one. 

Automation is expected to decrease production costs and time, ensure robustness of the process, and allow for the de-centralization of manufacturing.

We have developed our own unique approach to bioengineering human skin tissue composed of three modules: cell isolation (Semotiss™, CUTISS proprietary technology), cell expansion (Quantum®, TERUMO), and skin tissue formation (denovoCast™, CUTISS proprietary technology).

Clinical and scientific publications

2022

Two medical reports are currently in preparation

2021

First time compassionate use of laboratory engineered autologous Zurich skin in a massively burned child
more

2021

Expanding into the future: Combining a novel dermal template with distinct variants of autologous cultured skin substitutes in massive burns
more

2019

A Cultured Autologous Dermo-epidermal Skin Substitute for Full-Thickness Skin Defects: A Phase I, Open, Prospective Clinical Trial in Children
more

2017

The Effect of Wound Dressings on a Bio-Engineered Human Dermo-Epidermal Skin Substitute in a Rat Model
more

2016

Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineering
more

2014

Bioengineering dermo-epidermal skin grafts with blood and lymphatic capillaries
more

Medical Conferences

December 19th

1x talk:
Scar Revision Using Skin Substitutes - Esther Middelkoop (Plastic, Reconstructive & Hand Surgery, Amsterdam Movement Sciences, AUMC, Vrije Universiteit Amsterdam)

March 19th

2x talks:
denovoSkin use in burns - Esther Middelkoop & denovoSkin use in compassionate burns – Clemens Schiestl (KISPI)

April 7th – 9th

Exhibition/Booth
1 talk:
denovoSkin use in compassionate burns – Clemens Schiestl

May 28th – 30th

Exhibition/Booth
2x talks:
denovoSkin use in burns – Esther Middelkoop

June 14th – 18th

Exhibition/Booth

January 2023

Exhibition/Booth

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