swissinfo.ch: Swiss start-up develops world’s first ‘personalised skin’ machine

swissinfo.ch  “A Swiss company is offering hope to the more than 11 million people worldwide who suffer serious burns every year. The company is launching a revolutionary machine capable of generating skin that can be grafted in large quantities using a sample provided by the patient.” read more Photo: Copyright CSEM Newsroom LInk to article on …

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TeleTicino: “Skin-Machine from Switzerland”

TeleTicino, Ticinonews 2e edizione 24.6.2021 Interview with Dr. Daniela Marino and reportage on CUTISS’s unveiling of the denovoCast, the world’s first automated machine to produce customized skin tissue grafts for adults and children with severe skin injuries, such as deep burns.  Watch the interview and reportage starting at minute 12:43.  Newsroom LInk to video

CUTISS develops world’s first machine to produce personalized human tissue

CUTISS develops world’s first machine to produce personalized human skin tissue therapy A world-first innovation in tissue engineering and regenerative medicine that can lead to life-saving and life-changing medical treatments for millions of people with severe skin injuries Over 11 million people annually suffer from severe burns needing surgery Significant milestone in the company’s automation …

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First ever compassionate use of denovoSkin delivers proof of principle

The latest edition of Burns Open, the peer reviewed international journal, has published the case report of the first ever compassionate use of denovoSkin in a child patient.

The patient had experienced a 95% total body surface area (TBSA) deep flame burn, and the use of a bio-engineered dermo-epidermal skin graft was therefore justified and permitted. A total of 1,626 cm2 of denovoSkin was transplanted onto the patient (approximately 20% TBSA).

This first large-scale application of denovoSkin reported:

– Ease of handling and application
– Excellent engraftment rates (80 – 90%) over dermal substitutes as well as over allodermal remnants
– Soft and solid, close to natural skin coverage, after a maturation process

As such, the reported case has delivered the clinical proof of principle that denovoSkin has the potential to help substantially in severe and acute burns.

It must be noted that, despite the promising skin grafting and healing process, the patient sadly died from multiple organ failure unrelated to the grafts. We believe that in the future, if denovoSkin can be applied sooner and in greater quantities in such disastrous cases, then it could lead to life-saving outcomes.

As the authors in the report conclude, the prospect of scaling up denovoSkin to provide more rapid response and treatment for major burns would be “a paradigm shift in the care of such patients”.

The full report case can be read online, see link below.

denovoSkin has Orphan Drug Designation for the treatment of partial and full thickness burn wounds by Swissmedic, EMA, and FDA. It is currently in Phase II clinical trials comparing denovoSkin to conventional split-thickness skin grafts.

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