Clinical Problem – Scars
Worldwide, millions of people suffer from severe skin defects requiring surgical interventions to restore skin function. Existing therapies frequently leave these patients with permanent, painful, disfiguring, and debilitating scars. Scars may impair mobility and growth, and often require several follow-up surgeries, intense homecare and psychosocial rehabilitation.
Human skin is mainly composed of an outer epidermis and a lower dermis. The components of the dermis control and regulate scarring. Today, standard of care consists in harvesting a thin layer of healthy patient’s skin (autograft), which contains the epidermis but only remnants of the dermis. Since sufficient dermis is missing, these autografts often develop into scars.